Richard A. Davis, Ph.D., DABT

Biography

Rick Davis has over 25 years of experience in product safety, occupational health and regulatory affairs for the chemical, agricultural and pharmaceutical industries. He was certified in general toxicology and has been a Diplomate of The American Board of Toxicology since 1980, their charter year. His principal areas of expertise include safety evaluation and risk assessment. His primary goal has been to develop the means to permit the safe and effective use of products. He also served as a member and was a key contributor to the activities of several industry trade associations, including The European Crop Protection Association Toxicology Expert Group, The Chemical Industry Council/New Jersey Risk Assessment Task Force, The Formaldehyde Institute, and The Ethylene Oxide Industry Council, among others. He also holds an appointment as Adjunct Associate Professor and teaches online in the Toxicology Program at the University of Medicine & Dentistry of New Jersey, School of Health Related Professions.

FDA Experience

• Testing and registration of pesticides, animal drugs and other indirect food additives
• Threshold of Regulation exemption for substances in contact with food
• Safety testing and evaluation of pharmaceuticals and over-the-counter drug products
• Toxicology and safety pharmacology reviews for pharmaceutical IND and NDA submissions
• Risk assessment of pharmaceutical degradation products and impurities
  

Resume

Education

The Ohio State University - Columbus, Ohio - Ph.D., 1975 Pharmacology - B.S., 1970 Cell Biology

Certification

The American Board of Toxicology - Certified in General Toxicology, 1980

Re-certified 1985, 1990, 1995, 2000 and 2005

Employment

1999 - Present    Regulatory Toxicology Consultant - ToxSolutions - Flemington, NJ

1999 - 2006        Associate Professor and Faculty Member (part-time) - Toxicology Program - 
                             Department of Clinical Laboratory Sciences - School of Health Related
                             Professions University of Medicine & Dentistry of New Jersey, Newark, NJ 

1994 - 1999        Senior Product Registration Manager - American Cyanamid Company -                              Agricultural Products Research Division - International Regulatory Affairs,
                             Princeton, NJ

1992 - 1994       Program Manager - American Cyanamid Company - Cyanamid Agricultural
                            Research Center - Toxicology Department, Princeton, NJ

1989 - 1992       Manager, Toxicology Operations - American Cyanamid Company - Chemicals
                            Group Toxicology and Product Safety Department, Wayne, NJ

1983 - 1989       Toxicology Program Manager - American Cyanamid Company - Chemicals Group -
                            Toxicology and Product Safety Department, Wayne, NJ

1979 - 1983       Staff Toxicologist - Celanese Corporation - Department of Environmental,
                            Health and Safety Affairs, New York, NY

1975 - 1979       Division Pharmacologist / Physiologist - U. S. Air Force - 6570th Aerospace Medical                             Research Laboratory -Toxic Hazards Division, Wright-Patterson Air Force Base, OH

Academic Appointments

• Adjunct Associate Professor - Pharmaceutical and Product Safety Evaluation Professionals Track - Master of Science in Health Sciences Program - University of Medicine & Dentistry of New Jersey - School of Health Related Professions - Department of Clinical Laboratory Sciences, 2006 - Present
• Adjunct Faculty Member and Lecturer - Georgian Court College - Graduate School of Arts and Sciences - Department of Biology, 2003 - 2005
• Adjunct Assistant Professor, Toxicology Program - University of Medicine & Dentistry of New Jersey - School of Health Related Professions - Department of Clinical Laboratory Sciences, 1993 - 1999

Committee Assignments & Positions

2001 - Roche Vitamins Community Advisory Panel - Environmental Risk Assessment Consultant

1996 - 1999 - European Crop Protection Association - Toxicology Expert Group

1994 - 1997 - American Home Products Corporation - Occupational Health Committee

1993 - 1994 - Chemical Industry Council/New Jersey - Risk Assessment Task Force

1993 - New Jersey Environment Advisory Task Force - Appointed by the NJ State Senate President

1992 - 2004 - Thesis Advisory Committees - UMDNJ - New Jersey Medical School - Graduate                              School of Biomedical Sciences - Department of Pharmacology and Toxicology

• "The Interaction of Paraoxon with Human Recombinant Acetylcholinesterase", Clint Rosenfeld, B.S., July 14, 2004
• "Studies on the Hepatotoxicity of Flunitrazepam and Alcohol in Combination", Mahmoud Assaf, M.S., 1998
• "Pharmacokinetics and Pharmacodynamics of Benzophenone-3 in the Rat", Chukwuemeka S. Okereke, Ph.D., 1994
• "Functional and Pharmacokinetic Studies on the Interaction of Aspirin and Salicylamide in Rats", Maged M. Rizk, M.D., Ph.D., 1992

1992 - 1994 - American Cyanamid Company - Agricultural Research Division - Institutional Animal
                        Care and Use Committee - Corporate Occupational Health Committee

1991 - 1992 - Acrylonitrile Group - Chairman, Health and Safety Committee, Steering Committee

1990 - 1992 - American Industrial Health Council, Scientific Committee

1990 - 1992 - Chemical Manufacturers Association, Risk Assessment Task Group

1990 - 1992 - New Jersey Hazardous Substances Management Research Center - Health Effects
                        Assessment Division, Advisory Board

1989 - 1991 - The Formaldehyde Institute - Board of Directors Chairman, Science and Health
                         Committee

1984 - 1992 - American Cyanamid Company - Chemicals Group Label Committee

1982 - 1983 - Chemical Manufactures Association - Alcohols Panel - Alkyl Epoxides Panel

1982 - 1983 - Ethylene Oxide Industry Council

1981 - 1983 - Acrylate Industry Ad Hoc Testing Group

1981 - 1982 - Chemical Manufactures Association - Toxic Substances Control Act Testing 
                        Committee

Professional Memberships

2001 - Present - American College of Toxicology

1994 - Present - International Society of Regulatory Toxicology and Pharmacology

1990 - Present - The Society of Toxicology

1990 - Present - Society for Risk Analysis

Articles

• Davis, Richard, Michael Dourson, Bette Meek, Margaret Miller, Jay Murray, Bruce Naumann and Edward Ohanian.  “A National and International Debate on Default Uncertainty Factors vs. Data-Derived Uncertainty Factors.”  Human and Ecological Risk Assessment, 8(4), 895-911, 2002.
• Kadry, Abdelrazak M., Chukwuemeka S. Okereke, Mohamed S. Abdel-Rahman, Marvin A. Friedman, and Richard A. Davis.  "Pharmacokinetics of Benzophenone-3 After Oral Exposure in Male Rats."  Journal of Applied Toxicology, 15 (2), 97-102, 1995.
• Okereke, Chukwuemeka S., Abdelrazak M. Kadry, Hosni Hosni, Mohamed S. Abdel-Rahman, Richard A. Davis, and Marvin A. Friedman.  "Metabolism of Benzophenone-3 in Rats."  Drug Metabolism and Disposition, 21 (5):  788-791, 1993.
• Grammer, Leslie C., Martha A. Shaughnessy, Richard A. Davis and Roy Patterson.  "Exposure to TMXDI® (meta) Aliphatic Isocyanate and TMI® (meta) Unsaturated Aliphatic Isocyanate."  Journal of Occupational Medicine, 35 (3):  287-290, 1993.
• Daston, G.P., S.D. Gettings, B.D. Carlton, M. Chudkowski, R.A. Davis, A.L. Kraus, C.F. Luke, R.E. Quellette, T.A. Re, A.M. Hoberman and C.P. Sambuco.  "Assessment of the Reproductive Toxic Potential of Dermally Applied 2-Hydroxy-4-Methoxybenzophenone to Male B6C3F1 Mice."  Fundamental and Applied Toxicology, 20 (1):  120-124, 1993.
• Davis, Richard A.  "The Assessment of Safe Formaldehyde Occupational Exposure Limits."  Comments on Toxicology, 4 (4):  331-347, 1992.
• Davis, Richard A.  "Current Issues in Formaldehyde:  An Overview."  Comments on Toxicology, 4 (4):  265-267, 1992.
• Abdel-Nabi, Ismail M., Addelrazak M. Kadry, Richard A. Davis and Mohamed S. Abdel-Rahman.  "Development and Validation of a High-Performance Liquid Chromatographic Method for the Determination of Benzophenone-3 in Rates."  Journal of Applied Toxicology 12 (4):  255-259, 1992.
• Davis, Richard A.  "Toxicology of Powder Coating Crosslinkers."  Modern Paint and Coatings, pp 44-45, April 1992.
• Goodrich, Mark S., Mark J. Melancon, Richard A. Davis and John J. Lech.  "The Toxicity, Bioaccumulation, Metabolism, and Elimination of Dioctyl Sodium Sulfosuccinate DSS in Rainbow Trout (Oncorhynchus Mykiss)."  Water Research, 25 (2):  119-124, 1991.
• Pereira, M.A., M.M. Khoury, H.P. Glauert and R.A. Davis.  "Screen of Five Alkyl Carbamates for Initiating and Promoting Activity in Rat Liver."  Cancer Letters, 57:  37-44, 1991.
• Vernon, Patricia A. and Richard A. Davis.  "Acute Toxicologic Evaluation of m-TMXDI/TMP Adduct."  Acute Toxicity Data 1 (2):  106-107, 1990.
• Vernon, Patricia A. and Richard A. Davis.  "Acute Toxicologic Evaluation of MAGME."  Acute Toxicity Data 1 (1):  46-47, 1990.
• Vernon, Patricia A. and Richard A. Davis.  "Acute Toxicologic Evaluation of m-TMXDI."  Acute Toxicity Data 1 (1):  45-46, 1990.
• Vernon, Patricia A. and Richard A. Davis.  "Acute Toxicologic Evaluation of meta-DIPEB."  1(1):  44-45, 1990.
• Vernon, Patricia A. and Richard A. Davis.  "Acute Toxicologic Evaluation of meta-TMI."  Acute Toxicity Data 1 (1):  43-44, 1990.
• Miller, G.A., R.A. Davis, and J.C. Caporossi.  "Toxic Gas Replacements For Semiconductor Processing."  Semiconductor Safety Association Journal 4 (3):  7-11, 1990.
• Mackenzie, K., S. Henwood, G. Foster, F. Akin, R. Davis, P. DeBaeke, G. Sisson and G. McKinney.  "Three-Generation Reproduction Study with Dioctyl Sodium Sulfosuccinate (DSS) in Rats."  Fundamental and Applied Toxicology, 15:53-62, 1990.
• Davis, R.A., C.T. Olson, R.N. Terpolilli and K.C. Back.  "Acute Toxicity Studies of Triaminoguanidine Nitrate."  Proceedings of the JANNAF Interagency Propulsion Committee, 1978.
• Davis, R.A., C.T. Olson, R.N. Terpolilli and K.C. Back.  "Toxicity Studies of Triaminoguanidine Nitrate."  AMRL Report No. AMRL-TR-77-16, 1977.
• Davis, Richard A., Ralph N. Terpolilli and Kenneth C. Back.  "Toxic Point Determination of Selected Hazardous Materials."  Dept. of Transportation Report No. DOT/MTB/OHMO - 75/4, 1975.

Monographs, Chapters & Book Reviews

• Davis, Richard A.  Book Review: "Toxicology and Regulatory Process". International Journal of Toxicology 25, 541-543, 2006.
• Davis, Richard A.  "Aliphatic Nitro, Nitrate and Nitrite Compounds," Chapter 10 in Patty's Industrial Hygiene and Toxicology, Fourth Edition, Volume 2, Part A, G.D. Clayton and F.E. Clayton eds., John Wiley and Sons, Inc., 1993.
• Davis, Richard A.  "Studies on Emetine Cardiotoxicity in Guinea Pigs."  Ph.D. Dissertation, The Ohio State University, 1975.

Abstracts & Presentations

• Ford, R., R. Davis and D. Gardner. "Development of Inhalation Thresholds of Concern for the Evaluation of Tobacco Additives" The Toxicologist, 90 (1): #2317, 2006.
• Davis, Richard A. “Uncertainty Factor Accuracy: Data-Derived Factors are Better Than Default Factors” A National and International Debate on Default Uncertainty Factors vs. Data-Derived Uncertainty Factors, 5th Annual Conference on 10X Uncertainty Factors. University of Medicine and Dentistry of New Jersey, Newark New Jersey. June 1, 2001.
• Okereke, C.S., A.M. Kadry, M.S. Abdel-Rahman, R.A. Davis, and M.A. Friedman.  "Species Differences in Disposition of Benzophenone-3 After Oral Administration in Male Rat and Mouse."  The Toxicologist, 13 (1):  286, 1993.
• Kadry, A.M., H. Hosni, C.S. Okereke, M.S. Abdel-Rahman, R.A. Davis and M.A. Friedman.  "Pharmacokinetics of Benzophenone-3 in Rats."  The Pharmacologist 34 (3):  182, 1992.
• Okereke, C.S., H. Hosni, A.M. Kadry, M.S. Abdel-Rahman, R.A. Davis and M.A. Friedman.  "Metabolism of Benzophenone-3 in Rats."  The Pharmacologist 34 (3):  179, 1992.
• Grammer, L.D., M.A. Schaughnessy, R.A. Davis and R. Patterson.  "Clinical and Immunologic Evaluation of 95 Workers Exposed to Meta-Tetramethylene Xylene Diisocyanate (TMXDI) and Dimethyl-M-Isopropenyl Benzyl Isocyanate (TMI)."  Journal of Allergy and Clinical Immunology 87 (1, Part 2), #245, 1991.
• Davis, R.A., T.M. Federici and M.A. Friedman.  "A Dermal Carcinogenicity Study of MAGME®-100 Monomer."  The Toxicologist 11 (1):  333, 1991
• Burleigh-Flayer, H.D., D.E. Dodd, M.A. Friedman and R.A. Davis.  "The Effects of Meta-Tetramethylene Diisocyanate (m-TMXDI) Vapor on Respiratory Rate and Tidal Volume of Swiss Webster Mice and Sprague-Dawley Rats."  The Toxicologist 10 (1):  205, 1990.
• Davis, R.A., H.D. Burleigh-Flayer, D.E. Dodd and M.A. Friedman.  "A 90-Day Inhalation Toxicity Study of m-TMXDI (Meta-Tetramethylene Diisocyanate) in Mice and Rats."  The Toxicologist 10 (1):  204, 1990.
• Pereira, M.A., H.P. Glauert, M.M. Khoury, P. Barnwell, M. Hensley and R.A. Davis.  "Test of Alkyl Carbamates for Tumor Initiation and for Tumor Promotion in Rat Liver."  The Toxicologist 9(1):  214, 1989.
• Ouelette, R.E., C.S. Auletta and R.A. Davis.  "Closed-Patch Repeated Insult Dermal Sensitization Study in Guinea Pigs with Glyoxal."  The Toxicologist 9 (1):  242, 1989.
• Davis, R.A. and M.A. Friedman.  "A Canine 90-Day Gavage Study of MAGME®-100 Monomer."  The Toxicologist 9 (1):  198, 1989.
• Mackenzie, K., S. Henwood, G. Foster, F. Akin, R. Davis, P. DeBaeke, G. Sisson and G. McKinney."  Three-Generation Reproduction Study with Dioctyl Sodium Sulfosuccinate (DSS) in Rats."  The Toxicologist 7 (1):  176, 1987.
• Rodwell, D.E., R.A. Davis, E.J. Tasker and M. A. Friedman.  "A Fertility and General Reproductive Performance Study in Rats with a Teratology Phase on Diethylene Glycol."  The Toxicologist 7(1):  145, 1987.
• Davis, Richard A., and Marvin A. Friedman.  "m-TMXDI:  An Isocyanate Which Does Not Cause Pulmonary Sensitization in Guinea Pigs."  The Pharmacologist 28 (3):  178, 1986.
• Davis, R.A., J.C. Siglin, P.J. Becci, M.A. Friedman.  "Acute Toxic Effects of Acrylic Monomers on the Rat Forestomach with Gavage Administration."  The Toxicologist 6 (1):  188, 1986.
• Davis, R.A., J.C. Siglin, P.J. Becci, M.A. Friedman.  "Concentration Dependence and Reversibility of Gastric Lesions Induced By Repeated Gavage of Acrylic Monomers."  The Toxicologist 6 (1):  188, 1986.
• Davis, R.A., C.S. Auletta, and M.A. Friedman.  "Isocyanate Dose-Related Dermal Irritation and Delayed Contact Hypersensitization in Guinea Pigs."  The Toxicologist 5 (1):  251, 1985.
• Koshchier, F.J., M.A. Friedman, R.A. Davis, and R. Gay.  "Rabbit Alveolar Macrophage (RAM) Cytotoxicity Assay Performed on Metal Coated Graphite Fibers."  The Toxicologist 4 (1):  2, 1984.
• Davis, R.A., C.S. Auletta, G.M. Benke and J.J. Clary.  "Tripropylene Glycol Diacrylate (TRPGDA) Toxicity with Repeated Dermal Exposure."  The Toxicologist 3 (1):  152,1983.
• Davis, R.A., M.E. George, K.C. Back.  "Muscimol Antagonizes Methyhydrazine Induced Convulsions."  Toxicology and Applied Pharmacology 48 (1):  A197, 1979.
• Terpolilli, R.N., R.A. Davis, K.C. Back.  "A Comparative Study of the Effects of Three Halogenated Methanes on Cardiovascular Dynamics and Myocardial Energy Metabolism."  Toxicology and Applied Pharmacology 48 (1):  A22, 1979.
• Terpolilli, R.N., R.A. Davis, G.R. Peterson and K.C. Back.  "The Effects of Bromochlorodifluoromethane (BCF) on Contractility and Cardiac Tissue Levels of High Energy Metabolites."  Toxicology and Applied Pharmacology 45 (1):  336, 1978.
• Davis, R.A., and K.C. Back.  "The Effects of Bromochlorodifluoromethane (BCF) and MN++ on Rate Dependent Changes in Contractility of Isolated Atria."  Toxicology and Applied Pharmacology 45 (1):  227, 1978.
• Davis, R.A., J.O. Lindower and P.B. Hollander.  "Uptake, Subcellular Distribution and Toxicity of 3H-Emetine During Chronic Administration."  Federation Proceedings 33 (3 Part I):  1656, 1974.
• Davis, R.A. and P.B. Hollander.  "Subcellular Distribution of Emetine-3H in Isolated Perfused Guinea-Pig Heart."  The Pharmacologist 15 (2):  #329, 1973.
• Hollander, P.B., R.A. Davis, and B.H. Marks.  "Influence of Extracellular Potassium Concentrations on Ouabain-Induced Changes of Transmembrane Potential and Contractile Characteristics."  The Pharmacologist 13 (2):  #40, 1971.
• Davis, Richard and Philip B. Hollander.  "Alteration of Transmembrane Potential Configuration Coincident with Glycoside-Induced Cardiac Arrhythmia."  The Pharmacologist 13 (2):  #42, 1971.