• Reviewed food additive petitions and authored regulations on food irradiation, retortable pouches, adhesives, and plastics
• Participated in an internal review and evaluation of issues pertaining to the total food label
• Monitored indirect additive petition review as Project Officer in the Food Additives Program
• Conducted an analysis of the time needed to complete reviews of food additive petitions
• Dealt with controversial issues on the use of various food additives and GRAS ingredients, such as food irradiation and monosodium glutamate
• Detailed to supervise the Direct Additives Branch dealing with direct food additives, color additives, and GRAS petitions for several months
• Involved in Congressional hearings, FDA briefings, and talks and lectures to industry, international visitors and the public on the subject of food             irradiation

As a consultant,

• Provided expert consultative advice on regulatory issues regarding food and animal feed, food irradiation, drugs, devices, and labeling, with expertise in food additive petitions (direct, indirect and animal feed additives), GRAS, FCS, and NDI notifications, expert panel management, low acid canned food registration, and food labeling,
• Considered an international expert on food irradiation and was a temporary advisor to World Health Organization (WHO) on food irradiation in 1997 – 1998.

Phoenix Regulatory Associates, LTD. - Sterling, Virginia - 1991 to Present

As a Senior Consultant, provides expert consultative advice on regulatory issues regarding food and animal feed, food irradiation, drugs,devices, and labeling, with expertise in food additive petitions(direct, indirect and animal feed additives), GRAS, NDI and FCS notifications, expert panel management, food labeling, and the CMC sections of INDs, NDAs, ANDAs, and DMFs.  He is considered an international expert and was contracted by FDA to draft an expert report on MSG.  He has directed major compliance projects for pharmaceutical, medical device and food companies. He has also managed large projects to aid pharmaceutical companies in meeting consent decree requirements.  He was a temporary advisor to World Health Organization (WHO) on food irradiation in 1997 - 1998.

Hazelton Corporation - Herndon, Virginia - 1990 to 1991

As a senior consultant on foods in Hazleton’s Regulatory Affairs Division,provided senior consulting services for regulatory issues regarding GRAS ingredients, food additives and animal feed additives. In this capacity, acted as liaison for clients on matters before the U.S. Food and Drug Administration.

Division of Food and Color Additive - Food and Drug Administration - 1977 to 1990

As a consumer safety officer in the Food Additives Policy Staff,Division of Food and Color Additives, Center for Food Safety and Applied Nutrition, dealt with controversial issues raised by the use of various food additives and GRAS ingredients, such as food irradiation and monosodium glutamate. Conducted an analysis of the time needed to complete reviews of food additive petitions. Also detailed to supervise the Direct Additives Branch dealing with direct food additives, color additives, and GRAS petitions for several months. Monitored indirect additive petition review as Project Officer in the Food Additives Program. Authored regulations on food irradiation, retortable pouches, adhesives, and plastics. Involved in Congressional hearings, FDA briefings, and talks and lectures to industry,international visitors and the public on the subject of food irradiation.

Department of Pharmacology - Medical University of South Carolina - 1975 to 1977

Managed the laboratory and conducted research on membrane receptors and protein-lipid-protein interaction. Instructed graduate students and medical students topics in molecular pharmacology and experimental methods in pharmacology.

National Heart Lung Institute - National Institute of Health - 1973 to 1975

Conducted research and published articles on the sodium potassium AT Pase membrane receptor system.

Earlier Experience

• 1969 to 1973: School of Pharmacy, University of Wisconsin, Research and Teaching Assistant
• 1967 to 1969: McArdle Institute for Cancer Research, University of Wisconsin, NIH Fellow
• 1965 to 1967: Dept. of Food Science and Technology, University of Hawaii, Research Assistant

Education

• 1973, Ph.D., Pharmaceutical Biochemistry, University of Wisconsin,
• 1967, M.S., Food Science, University of Hawaii,
• 1965, B.A., Chemistry, University of Hawaii.

Honors

• FDA Commendable Service Award, 1985 and 1990.
• Outstanding performance rating at FDA for 5 years.
• Pharmacology Research Associate, NIGMS, NIH 1973–1975
• Eagle Scout with Bronze Palm

Membership

• Institute of Food Technologists since 1965
• American Chemical Society since 1965
• Regulatory Affairs Professional Society
• Drug Information Association
• Parenteral Drug Association

Publications

• Takeguchi, C.A. and H.Y. Yamamoto, Light-induced 18O2 uptake by epoxy xanthophylls in New Zealand spinach leaves ( Tetragonia expansa ). Biochim. Biophys. Acta 153: 459, 1968.
• Sih,C.J., C. Takeguchi and P. Foss, Mechanism of prostaglandinbiosynthesis. III. Catecholamines and serotonin as coenzymes. J. Am. Chem Soc. 92: 6670, 1970.
• Takeguchi,C., K. Kohno and C.J. Sih, Mechanism of prostaglandin biosynthesis. I.Characterization and assay of bovine prostaglandin synthetase. Biochemistry 10: 2372, 1971.
• Foss, P., C. Takeguchi, H. Tai, and C. Sih, Mechanism of prostaglandin biosynthesis. 18O2 Studies on PGF1. Ann. N.Y. Acad. Sci., Conference on Prostaglandins, 17-19 Sept. 1970, New York, 180: 126, 1971.
• Foss, P., C. J. Sih, C. Takeguchi, and H. Schnoes, Biosynthesis and chemistry of 11-dehydro PGF1a. Biochemistry 11: 227, 1972.
• Takeguchi,C. and C.J. Sih, A rapid spectrophotometric assay for prostaglandinsynthetase: Application to the study of non-steroidal antiinflammatoryagents. Prostaglandins , 2, 169, 1972.
• Yamamoto, H.Y., and C.A. Takeguchi, Concepts on the role of epoxycarotenoids in plants. In Forti, G., M. Avron, and A. Melandri(eds.). Proceedings 2nd International Congress Photosyn. Research , Vol. 1, W. Junk, The Hague, 1972, pp.621-627.
• Sih, C.J. and C.A. Takeguchi, Biosynthesis of prostaglandins. In Ramwell, P. and J. Shaw (eds.) Prostaglandins, Vol. 1, Chap. 3, Plenum Press, New York, 1973, p. 83.
• Chan, J.A., M. Nagasawa, C. Takeguchi and C.J. Sih, On agents favoring prostaglandin F formation during biosynthesis. Biochemistry 14: 2987, 1975 .
• Takeguchi, C.A., U.E. Honegger, W.W. Holland, and E.O. Titus, Evidence for subclasses of SH groups in (Na+ + K+)-ATPase. Life Sciences 190 :797, 1976.
• Halsey,J.F., D.B. Mountcastle, C.A. Takeguchi, R.L. Biltonen, and G.E.Lindenmayer, Detection of a ouabain-induced structural change in thesodium, potassium adenosine triphosphatase. Biochemistry 16: 432, 1977.
• Brunetti, A., V. Frattali, W. Greear, C. Takeguchi, and L. Valcovic,FDA requirements for irradiated meats and other irradiated foods. Proceedings of the International Meat Research Congress, ColoradoSpring, CO, August 31 to September 5, 1980.
• Brunetti, et. al., Recommendations for evaluating the safety of irradiated foods. Bureau of Foods, FDA, July, 1980.
• Kauffman, F.L., L. Valcovic and C. Takeguchi, U.S. FDA update on irradiated foods. Proceeding of the International Meeting on Radiation Processing , Japan, October 27-31, 1980.
• Takeguchi, C.A., Irradiated Foods--Criteria for deregulation. FDA Bylines , 11 :2106, October, 1981.
• Takeguchi, C.A., Regulatory aspects of food irradiation. Food Technology , February 1983:44.
• Takeguchi, C.A., Regulatory status of food irradiation. J. Food Safety , 5 :2113, 1983.
• Kauffman, F.L., C.A. Takeguchi and G.H. Pauli, The food irradiation regulatory picture in the United States. Radiat. Phys. Chem. , 22 :715, 1983.
• Takeguchi, C.A., FDA regulations for commercial food irradiation, in Radiation Disinfestation of Food and Agricultural Products ,Proceedings of an international Conference, Honolulu, HA, November14-18, 1983, Hawaii Institute of Tropical Agriculture and HumanResources, University of Hawaii Press, 1985.
• Pauli, G.H., and C.A.. Takeguchi, Food irradiation--an FDA perspective. Food Reviews International , 2 :79, 1986.
• Takeguchi, C.A., Irradiation of Poultry, The Toxicology Forum, Proceedings of the Annual Summer Meeting, Aspen, Colorado, July 12-17, 1988
• Takeguchi, C.A., Toxicological Considerations, in High-Dose Irradiation: Wholesomeness of food irradiated with doses above 10 kGy, A report of a Joint FAO/IAEA/WHO Study Group, WHO Technical Report Series 890, WHO, geneva, 1999.